BaSiS Research Study
BaSiS is a research study to see whether a booster vaccine will improve the body's immune responses in people who received the J&J vaccine through the SISONKE Phase IIIb implementation trial. Our researchers also want to know whether the time between SISONKE vaccination and a booster dose, HIV status and age affects these responses.
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COVID-19 Surveillance in Pregnant Women and Household Contacts
The Pregnancy Surveillance Study aims to evaluate the impact of SARS-CoV-2 in pregnancy and household contacts of pregnant women since there is insufficient research on this population. This study will determine the natural history of symptomatic SARS-CoV-2 infection in pregnancy, including the potential for vertical transmission, among HIV-uninfected pregnant individuals and those living with HIV.
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DAISY - Specific Aim 3
This project aims to measure acceptability of, and preferences for the DAISY drug delivery platform among two key end-user groups in South Africa (SA): caregivers of HIV-positive children receiving antiretroviral therapy (ART) and health care providers.
These end-user perspectives are linked to the Target Product Profile (TPP) and will inform design of the DAISY, including device and applicator characteristics.
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ENBEL
This project aims to bring together leading researchers and policy groups in the EU and Africa who are working on climate change and health. The consortium intends to support EU climate change and health programmes and policy making, as well as related activities in Africa. We aim to establish the CHANCE network (Climate and Health Africa Network for Collaboration and Engagement) consisting of leading policy makers in East and Southern Africa, who will work together to develop policies on climate change and health, and support countries in developing funding proposals for the Green Climate Fund.
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GBS EPI Study (1091006)
This study is being conducted within the setting of tertiary and secondary hospitals and their referring antenatal clinics and midwife obstetric units (MOU) in which the Phase I/II GBS clinical trial takes place. The aim is to estimate the incidence of obstetric and perinatal birth outcomes in a population as similar as possible to the population included in the Phase I/II trial. The data generated from this study will enable contextualization of emergent safety signals.
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Girls Achieve Power (GAP) Year Study
This program aims to empower adolescent girls in the areas of health, education, social and economic assets while shifting gender attitudes and encouraging positive behaviour change among adolescent boys. Utilizing an ecological model, GAP Year will work with schools, communities, parents, NGOs and health care facilities to encourage a culture of health and safety. Importantly we will also build the evidence base around the impact of asset-building approaches for adolescents
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HVTN805/HPTN093
Antiretroviral analytical treatment interruption (ATI) to assess immunologic and virologic responses in participants who initiated ART in early HIV infection after having received VRC01 or placebo in HVTN 703/HPTN 081
We are looking at the effect previous exposure to monoclonal antibodies and rapid ARV introduction will have on subsequent ability to suppress HIV viral load.
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IMPAACT 2019
Phase I/II Study of the Pharmacokinetics, Safety, and Tolerability
of Abacavir/Dolutegravir/Lamivudine Dispersible and Immediate Release Tablets in HIV-1-Infected Children Less than 12 Years of Age
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iPrEP-STI
Integrating HIV Pre-exposure Prophylaxis and diagnostic STI care: An individualised public health approach (iPrEP-STI). The aim of this study is to engage policy makers, healthcare providers and patients in discrete choice experiments to establish preferences for diagnosis and treatment of STIs and assess the feasibility of integrating these within the South African health-system.
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MSD V114
A Phase 3, Multicenter, Randomized, Double-blind, Active Comparator-controlled Study to Evaluate the Safety, Tolerability, and Immunogenicity of V114 Followed by Administration of PNEUMOVAX™23 Eight Weeks Later in Children Infected with Human Immunodeficiency Virus (HIV) (PNEU–WAY PED).
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MTN043
A Phase 3B, Randomized, Open-Label, Safety and Drug Detection Study of Dapivirine Vaginal Ring and Oral TRUVADA ® in Breastfeeding Mother-Infant Pairs.
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Novavax 2019nCOV501
This project aims to assess a Phase 2A/B, randomized, observer-blinded, placebo controlled study to evaluate the efficacy, immunogenicity, and safety of a SARS-cov-2 recombinant spike protein nanoparticle vaccine (SARS-cov-2 RS) with matrix-adjuvant in South African adult subjects living without HIV; and safety and immunogenicity in adults living with HIV
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NVX2019nCOV501
A phase 2A/B, randomized, observer-blinded, placebocontrolled study to evaluate the efficacy, immunogenicity, and safety of a SARS-CoV-2 recombinant spike protein nanoparticle vaccine (SARS-CoV-2 rS) with matrix-m1â„¢ adjuvant in South African adult subjects living without HIV; and safety and immunogenicity in adults living with HIV
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Operation Gophelega
Wits RHI's new PEPFAR-funded district support programme for HIV and TB prevention, care and treatment. Following an application submitted in April 2021, in early August 2021 Wits RHI received notification that our application was successful and that we are being asked to continue to support Tshwane, and in addition, to take over the CDC-funded support activities in Ekurhuleni.
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STI_Zoli001
A multi-centre, randomized, open-label, noninferiority trial to evaluate the efficacy and safety of a single, oral dose of zoliflodacin compared to a Combination of a single intramuscular dose of Ceftriaxone and a single oral dose of azithromycin in the Treatment of patients with uncomplicated gonorrhoea
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V114-030
A Phase 3, Multicenter, Randomized, Double-blind, Active Comparator controlled Study to Evaluate the Safety, Tolerability, and Immunogenicity of V114 Followed by Administration of PNEUMOVAX™23 Eight Weeks Later in Children Infected with Human Immunodeficiency Virus (HIV) (PNEU-WAY PED)
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Wits RHI PEPFAR COVID-19 Response
Wits RHI PEPFAR funded programmes (Tshwane CDC, Lejweleputswa APACE and Key Populations - USAID) in collaboration with PASP-ELMA, Project PrEP-UNITAID, and School-Based Programme - USAID) have established a PEPFAR RHI COVID-19 Response Committee which serves as a nerve centre to coordinate an internal Wits RHI COVID-19 response and to leverage resources and best practices between the programmes.
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OPTIMIZE
The OPTIMIZE project is lead by a global consortium that aims to ensure the optimization of ART that people living with HIV receive. making sure these are the best-available ART in the most efficient and cost-effective manner possible.
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