Sinead Delany-Moretlwe, MBBCh PhD DTM&H is a Research Professor and Director: Research at Wits RHI at the University of the Witwatersrand, Johannesburg. A South African-born medical doctor, her research has focused on the intersections between sexual and reproductive health (SRH) and HIV, especially in adolescents. She has worked on several phase III trials of new HIV prevention technologies, including PrEP and is currently protocol chair of a phase III trial of injectable cabotegravir for HIV prevention in women affiliated to the HIV Prevention Trials Network (HPTN 084). A key thread of all her research has been successfully taking HIV and sexual and reproductive health interventions to scale within the South African and African context. She is an advisor to the South African National Department of Health PrEP technical working group and serves on several WHO and other advisory committees.