PrEP SMART: Evaluation of stepped PrEP adherence support for young South African women using a SMAR

Purpose
To test a stepped model of scalable adherence support strategies in South African young women who initiate PrEP, using a SMART design.

Primary Objectives
To evaluate:

• the proportion of young South African women who adhere well to PrEP with regular clinic visits and mHealth interventions alone,
• the proportion of women who adhere well to PrEP with intensified interventions (i.e. monthly visits and special issue counseling or quarterly visits and drug-level feedback),
• and the optimal sequence of intensifying adherence support among young women who have low adherence after the first two months of use.

Study population
HIV-uninfected women ages 18-25 in Johannesburg, South Africa.

Investigators
Sinead Delany-Moretlwe : Protocol Co-Chair

Latest Update: 15 February 2021

For more about PrEP SMART please email rhicomms@wrhi.ac.za