HOPE (HPV One and two dose Population Effectiveness) Study

This program aims to monitor the effectiveness of a 2-dose and 1-dose HPV vaccination schedules on community level HPV prevalence among South African adolescent girls

Primary Outcomes
In South African adolescent girls aged 17–18 years;
• To measure the population effectiveness of the national 2-dose vaccine schedule, delivered at age 9 years, in protecting against infection with sexually transmitted HPV16 and 18;
• To measure the population effectiveness of a 1-dose vaccine schedule, delivered via a demonstration project to girls in Grade 10 of public school, in protecting against infection with sexually transmitted HPV16 and 18; and
• To determine whether HIV infection status affects the protective effectiveness of HPV vaccines

Study population

Adolesecent girls aged 17-18 years in 2019, 2021, and 2023

Investigators

Prof. Sinead Delany-Moretlwe: Principal Investigator

Latest Update: 15 February 2021

For more about HOPE (HPV One and two dose Population Effectiveness) Study please email rhicomms@wrhi.ac.za