A Multi Center, Open‐Label, Randomised Clinical Trial Comparing HIV Incidence and Contraceptive Benefits in Women using Depot Medroxyprogesterone Acetate (DMPA), Levonorgestrel (LNG) Implant, and Copper Intrauterine Devices (IUDs).
The Evidence for Contraceptive Options and HIV Outcomes (ECHO) Study is an open-label randomised clinical trial comparing three highly effective, reversible methods of contraception—the progestogen-only injectable depot medroxyprogesterone acetate (DMPA), a progestogen implant called Jadelle and the copper IUD—to evaluate whether there is any difference in the risk of HIV acquisition among women using these methods. The study will also compare side effects, pregnancy rates and women’s patterns of use for the three contraceptive methods.
To compare the risks of HIV acquisition between women randomised to DMPA, LNG implant, and copper IUDs.
The ECHO Study is being conducted at 12 trial sites in four countries: Kenya, South Africa, Swaziland and Zambia.
Sexually active, HIV‐negative women, 16‐35 years old, seeking effective contraception, willing to be randomised to any of the study arms, and not desiring pregnancy for the duration of study participation.
Prof Helen Rees, National Principal Investigator
Dr. Thesla Palanee-Phillips, Site Principal Investigator
Dr. Aviva Ruch, Sub-Investigator
Dr. Eleanor Matta, Sub-Investigator
A consortium of donors is funding the study. They include:
Bill & Melinda Gates Foundation
US Agency for International Development (USAID)
Swedish International Development Cooperation Agency (SIDA)
United Nations Population Fund (UNFPA) and the Medical Research Council of South Africa.
In addition, USAID and the South African government are donating the contraceptives used in the study.
PARTNERS AND COLLABORATORS
South Africa - Aurum Institute in Klerksdorp, Desmond Tutu Foundation Emavundleni Research Centre in Cape Town, Effective Care Research Unit in East London, the Madibeng Centre for Research in Brits, Maternal, Adolescent and Child Health (MatCH) Research in Durban and Pietermaritzburg, the Qhakaza Mbokodo Research Clinic in Ladysmith, the Setshaba Research Centre in Shoshanguve and WRHI / University of the Witwatersrand in Johannesburg;
Kenya - KEMRI-RCTP Study Centre, Lumumba Health Centre, in Kisumu
Swaziland - Family Life Association of Swaziland and ICAP-Columbia in Manzini
Zambia, UNC Global Projects Zambia/Kamwala Clinic in Lusaka