ALIVE

ALIVE

SHORT TITLE
ALIVE

FULL TITLE
African Local Initiative for Vaccinology Expertise

SUMMARY
The Wits African Local Initiative for Vaccinology Expertise (ALIVE) is a vaccinology flagship programme addressing the need for increasing vaccinology research capacity in the African region, and will offer new opportunities for authoritative global research leadership. ALIVE is a university-wide partnership of internationally recognised scientists with a breadth of expertise across the discipline of vaccinology and over time will integrate both Wits and external scientists with an emerging interest in this field.

ALIVE’s mission is to create African leadership in vaccinology research and advocacy to protect people from vaccine preventable diseases. In practice this means that ALIVE, as an African/South African vaccine and immunisation research initiative, will develop a new cadre of African leadership and scientists aimed at development of new vaccines and at the introduction of new and existing vaccines into strengthened, effective immunisation programmes, with the goal of significantly reducing vaccine preventable diseases (VPDs) over the next 15 years. ALIVE’s objectives will be driven by rigorous basic science, clinical science, implementation science, public health, economic and social/behavioural science agendas. The research will focus on children, under- and un-immunized populations, HIV infected populations, HIV-exposed uninfected children, pregnant women, adolescents and the elderly. ALIVE will develop a multidisciplinary postgraduate programme in vaccinology and thus strengthen African research capacity, establishing Wits as a leading vaccinology institution.

OBJECTIVES
ALIVE’s objectives include:
• The development of new and improved vaccines; exploration of genomics on vaccine immunogenicity and effectiveness;
• Identification of correlates of immunisation;
• Optimisation of vaccine schedules;
• Improved vaccine delivery strategies;
• Vaccine introduction to new populations;
• Modelling and cost-effectiveness studies;
• Improving vaccine demand, confidence and communication
• Building African vaccinology research capacity.

SITE LOCATIONS


POPULATION
INVESTIGATORS
Professor Helen Rees, Co-Director
Professor Shabir Madhi, Co-Director

DONORS/SPONSORS
Bill & Melinda Gates Foundation and National Research Foundation

PARTNERS AND COLLABORATORS
Basic Science
Professor Bavesh Kana, Reader, Early Career Scientist of the Howard Hughes Medical Institute and Head of the DST/NRF Centre of Excellence for Biomedical TB Research (CBTBR) Centre, University of the Witwatersrand and National Health Laboratory Service
Professor Lynn Morris, Chief Specialist Scientist and HIV Virology Section Lead in the Centre for HIV and STIs of the NHLS, Co-Director, HIV Vaccine Discovery Unit
Professor Penny Moore, Wellcome Trust Fellow at the NICD, and a Reader at the University of the Witwatersrand, Co-Director, HIV Vaccine Discovery Unit
Professor Michèle Ramsay, Professor in the Division of Human Genetics, National Health Laboratory Service and University of the Witwatersrand (Wits) and Head of the Sydney Brenner Institute
Dr Melinda Suchard, Head: Centre for Vaccines and Immunology, NICD and Associate Lecturer, Molecular Medicine and Haematology, University of the Witwatersrand
Professor Caroline Tiemessen, Centre of HIV & STI; DST/NRF Chair in HIV Vaccine Translational Research, NICD
Professor Maria Papathanasopoulos, Director: HIV Pathogenesis Research Unit; Co-director: Genotyping Laboratory, Department of Molecular Medicine and Haematology

Clinical Science
Dr Clare Cutland, Senior Medical Research Officer, with expertise in clinical trials, RMPRU
Dr Lee Fairlie, Paediatrician specialising in HIV/TB clinical trials, Senior Researcher, Wits RHI
Dr Michelle Groome, Senior Clinical Researcher and medical epidemiologist/vaccinologist, RMPRU
Dr Marta Nunes, Senior Scientist, RMPRU
Dr Neil Martinson, Director, Peri natal Research Unit (PHRU), University of Wits

Implementation Science, Modelling, Cost Effectiveness, and Social & Behavioural Research
Professor Sinead Delany-Moretlwe, Clinical Epidemiologist, Head of Postgraduate Studies, Wits RHI
Dr Saiqa Mullick, Clinical Epidemiologist, Director: Implementation Science, Wits RHI
Professor Clare Penn, Director, Health Communication Research Unit, University of Wits
Professor Jennifer Watermeyer, Deputy Director of the Health Communication Research Unit, Wits University
Dr Jonathan Stadler, Medical Anthropologist, Wits RHI
Professor Karen Hofman, PRICELESS, Wits School of Public Health

Subscribe to our Newsletter