COVID-19 Initiatives and Projects



Solidarity Study

The World Health Organization and partners are launching a large international clinical study to find out whether any of four COVID-19 treatments are effective. This is known as the Solidarity study.

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CROWN CORONATION

The purpose of this project is to assess the effectiveness of the Measles and Rubella (MR) and Measles, Mumps and Rubella (MMR) vaccines in preventing COVID-19 disease in healthcare workers.

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Wits RHI PEPFAR COVID-19 Response

Wits RHI PEPFAR funded programmes (Tshwane CDC, Lejweleputswa APACE and Key Populations - USAID) in collaboration with PASP – ELMA, Project PrEP – UNITAID, and School-Based Programme - USAID) have established a PEPFAR RHI COVID-19 Response Committee which serves as a nerve centre to coordinate an internal Wits RHI COVID-19 response and to leverage resources and best practices between the programmes.

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COVID-19 Surveillance in Pregnant Women and Household Contacts

The Pregnancy Surveillance Study aims to evaluate the impact of SARS-CoV-2 in pregnancy and household contacts of pregnant women since there is insufficient research on this population. This study will determine the natural history of symptomatic SARS-CoV-2 infection in pregnancy, including the potential for vertical transmission, among HIV-uninfected pregnant individuals and those living with HIV.

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The South African Ox1Cov-19 Vaccine VIDA-Trial

A randomized placebo-controlled study to determine the safety, immunogenicity, and efficacy of a new SARS-CoV-2 vaccine called ChAdOx1 nCoV-19.

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The COVID-19 Digital Risk Assessment and Mapping known as HealthCheck

In a collaborative effort, Wits RHI’s is collaborating with Praekelt and the NDOH to build a USSD and WhatsApp Digital Risk Assessment and Mapping Tool called “COVID-19 HealthCheck”. The NDOH WhatsApp platform that houses the HealthCheck tool, has become the most highly utilized platform for users in South Africa currently serving millions of South Africans.

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The EDCTP-COREP COVID-19 Household Cluster Investigation

This study aims to determine the epidemiological parameters of COVID-19 through a household transmission study in a rural area of South Africa.

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National testing and contact tracing across our PEPFAR-funded programmes: The Wits RHI PEPFAR COVID-19 Response committee

The committee serves as a nerve centre to coordinate the internal Wits RHI COVID-19 response and to leverage resources and best prac¬tices between the programmes. This committee response is guided by the Wits RHI Steering committee, PEPFAR and its agencies (USAID, CDC, UNITAID, and ELMA).

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Novavax 2019nCOV501

This project aims to assess a Phase 2A/B, randomized, observer-blinded, placebo controlled study to evaluate the efficacy, immunogenicity, and safety of a SARS-cov-2 recombinant spike protein nanoparticle vaccine (SARS-cov-2 RS) with matrix-adjuvant in South African adult subjects living without HIV; and safety and immunogenicity in adults living with HIV

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COVID Vaccine Implementation Science

A COVID-19 vaccine plan led by the Implementation Science team.

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HPTN084 CoVPN Preparedness Fund

To provide support to Ward 21 CRS #31966, to strengthen their site capacity to participate in large Phase 111 efficacy trials.

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The Health Care Worker Health and Wellbeing Study

This study focuses on health and mental wellbeing of health workers providing care to patients with COVID-19 in Johannesburg, South Africa: rapid needs assessment and action research.

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Jansen ENSEMBLE VAC31518COV3001 HG

This project aims to demonstrate the efficacy of AD26.COV2.S in the prevention of molecularly confirmed moderate to severe/critical COVID-19, as compared to Placebo, in SARS-CoV-2 Seronegative adults.

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COVID-19 Sero Survey

A cross-sectional COVID-19 survey involving questionnaires and seroprevalence, with the aim of measuring and understanding COVID-19 perceptions and impacts among residents of Hillbrow.

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B-Wise Social Media: Supporting SA Youth with HIV Edutainment Bursts

This initiative enables innovative solutions focusing on HIV prevention among vulnerable groups during the COVID-19 crisis.

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DAISY - Specific Aim 3

This project aims to measure acceptability of, and preferences for the DAISY drug delivery platform among two key end-user groups in South Africa (SA): caregivers of HIV-positive children receiving antiretroviral therapy (ART) and health care providers.
These end-user perspectives are linked to the Target Product Profile (TPP) and will inform design of the DAISY, including device and applicator characteristics.

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